/ en /synthetic-biomolecular-condensates-soft-living-interfaces <span>Synthetic Biomolecular Condensates at Soft Living Interfaces</span> <span><a title="View user profile." href="/users/mnlo230">mnlo230</a></span> <span><time datetime="2024-01-11T09:13:11-05:00" title="Thursday, January 11, 2024 - 09:13 am">Thu, 01/11/2024 - 09:13 am</time> </span> <div><p><strong>Abstract:</strong> The living cell is an intricate and synchronized organization with compartmentalization across diverse length scales. While intracellular compartments such as the lysosome and mitochondria are bound by membranes, cells also contain organelles, not confined by membranes, known as “biomolecular condensates”. Recent studies showed that many biomolecular condensates are viscoelastic materials formed from the phase separation of proteins and nucleic acids. The abrupt changes in composition and material properties of these condensates impair their biological function and are often associated with cancer, ribosomopathies, and aging disorders. Therefore, synthetic systems are required to create model biomolecular condensates in living systems. These systems aim to elucidate the biophysical principles of intracellular organization and diseases. In the first part of my talk, I will discuss our work on using protein oligomerization and sequence interactions <em>in vivo</em> to create multiphasic biomolecular condensates that mimic native condensate assemblies. We show that specific molecular and nanoscopic design principles can be exploited to design optogenetic fusion proteins that exhibit targeted condensation with high spatiotemporal resolution. Later in this talk, I will describe our work on synthetic polymers to form condensates that mimic the function of underwater adhesive proteins secreted by marine organisms such as mussels and sandcastle worms. In summary, the bioinspired design of macromolecules that form model biomolecular condensates represents new frontiers to ask fundamental questions on the behavior of mesoscopic biological assemblies in living cells and to inspire the design of novel functional materials.</p> <p><img data-entity-uuid="90add36f-2cea-4d23-86e5-0bdf91612af0" data-entity-type="file" src="/sites/default/files/inline-images/Narayanan%20-%20Graphical%20Abstract.jpg" alt="graphic" width="2420" height="857" loading="lazy"></p> </div> <div> <div class="field-label font-bold inline-block">Date: </div> <div class="field-items inline-block"> <div><time datetime="2024-01-25T17:00:00Z">Thursday, January 25, 2024 - 12:00 pm</time> - <time datetime="2024-01-25T18:00:00Z">Thursday, January 25, 2024 - 01:00 pm</time> </div> </div> </div> <div> <div class="field-label font-bold inline-block">Location: </div> <div class="inline-block">CP 114</div> </div> <div> <div class="field-label font-bold inline-block">Tags/Keywords: </div> <div class="field-items inline-block"> <div><a href="/tag/chemistry-seminar" hreflang="en">chemistry seminar</a></div> <div><a href="/tag/seminar-series" hreflang="en">seminar series</a></div> </div> </div> <div> <div class="field-label font-bold inline-block">Event Series: </div> <div class="field-items inline-block"> <div><a href="/event-type/chemistry-department-seminar" hreflang="en">����vlog�ٷ���� Department Seminar</a></div> <div><a href="/event-type/seminar-series" hreflang="en">Seminar Series</a></div> </div> </div> <ul class="links inline"><li><a href="/synthetic-biomolecular-condensates-soft-living-interfaces" rel="tag" title="Synthetic Biomolecular Condensates at Soft Living Interfaces" hreflang="en">Read more<span class="visually-hidden"> about Synthetic Biomolecular Condensates at Soft Living Interfaces</span></a></li></ul> Thu, 11 Jan 2024 14:13:11 +0000 mnlo230 1051552 at